Decline in NAD+ Level with Age

Graph based on data from Massudi, H., Grant, R., Braidy, N., Guest, J., Farnsworth, B., & Guillemin, G. J. (2012). Age-Associated Changes In Oxidative Stress and NAD Metabolism In Human Tissue. PLoS ONE, 7(7). doi:10.1371/journal.pone.0042357


NAD+ is Essential for Life

NAD+ stands for nicotinamide adenine dinucleotide.

It is a molecule found in every cell in the body that is used to power metabolism by enabling  the mitochondria – the ‘powerhouses of the cell’ to convert the food we eat into the energy our body needs to sustain all its functions. It is also required to “turn off” genes implicated in accelerating aging processes.1,2

Healthy mitochondrial function, is an important component of healthy human aging. Research shows that as we age, levels of NAD+ decline substantially. This decline leaves us at greater risk for neuro and muscular degeneration3, declines in our cardiometabolic health4 and our capacity for repair and resiliency.

Today, scientists believe NAD+ is key to increasing the amount of time we spend in good health.1-4


How does NR boost cellular energy?

  1. Belenky, P., Racette, F. G., Bogan, K. L., Mcclure, J. M., Smith, J. S., & Brenner, C. (2007). Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD. Cell, 129(3), 473-484. doi:10.1016/j.cell.2007.03.024
  2. Imai, S., & Guarente, L. (2014). NAD and sirtuins in aging and disease. Trends in Cell Biology, 24(8), 464-471. doi:10.1016/j.tcb.2014.04.002
  3. Frederick, D., Loro, E., Liu, L., Davila, A., Chellappa, K., Silverman, I., . . . Baur, J. (2016, August). Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle. Cell Metabolism, 24(2), 269-282. doi:10.1016/j.cmet.2016.07.005
  4. Gomes, A., Price, N., Ling, A., Moslehi, J., Montgomery, M. K., Rajman, L., . . . Sinclair, D. (2013). Declining NAD Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging. Cell, 155(7), 1624-1638. doi:10.1016/j.cell.2013.11.037