TruB3

About NR

NR is a Next-Generation Form of Vitamin B3
NR stands for nicotinamide riboside which is a member of the vitamin B3 family. It can be found naturally in trace amounts in milk.1,2 Other milk-derived products such as whey and yeast-containing foods are also presumed as natural sources of NR.
Within the vitamin B3 family, there are three individual members: niacin (also known as nicotinic acid or NA), nicotinamide (sometimes referred to as niacinamide or NAM) and nicotinamide riboside (NR). None of the forms are related to the nicotine found in tobacco, although their names are similar.

While, each of these very similar sounding compounds all belong to the vitamin B3 family, each molecule's structural uniqueness causes them to be used differently by the body.  These differences contribute to the varying effectiveness of each in the various endpoints for which they have been studied.
Pre-clinical studies1 have proven that there are significant differences in each of the B3 molecule’s ability to effectively support our body’s longevity promoting mechanisms, as well as cellular energy production.
What We Need to Know About Each of the Vitamin B3s

NA (nicotinic acid/niacin)

  • Discovered in the late 1930’s
  • Identified as a treatment for pellagra, which is the late stage of severe niacin deficiency. Pellagra was common in the southern US during the early 1900s where income was low and corn products were a major dietary staple.5
  • Found in foods including yeast, meat, fish, milk, eggs, green vegetables, beans, and cereal grains
  • The most commonly recognized B3 due to its use as a treatment for elevated cholesterol for decades
  • Known to cause an uncomfortable side effect called ‘flushing’ when taken as a supplement6
  • Tryptophan can be converted to niacin within the body, although the efficiency of conversion is low in humans6

Nam
(nicotinamide)

  • Discovered in the late 1930’s around the same time as NA
  • Derivative (metabolite) of NA6 and NR
  • Sometimes referred to as niacinamide
  • Became popular due to the fact that it is not known to cause flushing
  • The form of niacin typically used in nutritional supplements and in food fortification6
  • “Turns off” longevity promoting proteins within the cells called sirtuins when consumed in higher doses

NR (nicotinamide riboside)

  • Discovered in the 1940’s
  • Identified as a natural product found in trace amounts in milk in 2004 by Dr. Charles Brenner
  • At the same time, Brenner also discovered the gene (NRK1) which enables NR to boost NAD+ levels in humans1
  • “Turns on” or activates longevity promoting proteins (Sirt2)
  • Not known to cause flushing
To better understand these critical differences, you must understand more about the body’s key to unlocking cellular energy production – and that is called NAD+.
About NAD+
  1. Trammell, S. A., Schmidt, M. S., Weidemann, B. J., Redpath, P., Jaksch, F., Dellinger, R. W., Abel, E.D., Migaud, M.E., Brenner, C. (2016). Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nature Communications, 7, 12948. doi:10.1038/ncomms12948

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